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Article

Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population.

The British journal of ophthalmology - 1 May 2015

Barry Robert J, Alsalem Jawaher A, Faassen Juliet, Murray Philip I, Curnow S John, Wallace Graham R

Abstract excerpt

BACKGROUND: Transforming growth factor β (TGFβ) is an important immunoregulatory cytokine in regulatory T cell (Treg) and Th17-mediated pathology, including uveitis due to Behçet's disease (BD). Of the three isoforms, TGFβ2 is found at highest levels in the aqueous humour of uninflamed eyes. TGFβ signals through a cell-surface receptor comprising three subunits (TGFBR1, 2 and 3). TGFBR3 is considered necessary...

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Share to Behcet Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Share to Receptors, Transforming Growth Factor beta

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Source

Identifiers

PMID: 25677673
DOI: 10.1136/bjophthalmol-2014-306198

Genes

TGFBR3
TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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