Article
Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage.
Pathogens and disease - 1 Feb 2015
Jasper Deana K, Sigar Ira M, Schripsema Justin H, Sainvil Carlyn K, Smith Christopher L, Yeruva Laxmi, Rank Roger G, Murthy Ashlesh K, Widder Jared R, Ramsey Kyle H
Abstract excerpt
We have previously shown that Chlamydia muridarum has multiple genomic variants that concomitantly vary in their in vitro and in vivo phenotype. Herein, we used real-time polymerase chain reaction-based genotyping assays to query plaque-cloned isolates of C. muridarum for the frequency of eight selected polymorphisms. These strains had no history of passage in vivo since their original isolation from laboratory...
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