Article
Emergence of the first levofloxacin-resistant strains of Streptococcus agalactiae isolated in Italy.
Antimicrobial agents and chemotherapy - 1 Apr 2015
Piccinelli G, Gargiulo F, Corbellini S, Ravizzola G, Bonfanti C, Caruso A, De Francesco M A
Abstract excerpt
Of 901 group B streptococcus strains analyzed, 13 (1.4%) were resistant to levofloxacin (MICs of >32 μg/ml for seven isolates, 2 μg/ml for four isolates, and 1.5 μg/ml for four isolates). Mutations in the quinolone resistance-determining regions (QRDRs) of gyrase and topoisomerase IV were identified. A double mutation involving the Ser-81 change to Leu for gyrA and the Ser-79 change to Phe or to Tyr for parC was...
Topics
- Anti-Bacterial Agents
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type I
- Drug Resistance, Bacterial
- Italy
- Levofloxacin
- Microbial Sensitivity Tests
- Mutation
- Streptococcus agalactiae