Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.

doi:10.1161/ATVBAHA.114.305176

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Article

Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Huan Tianxiao, Rong Jian, Tanriverdi Kahraman, Meng Qingying, Bhattacharya Anindya, McManus David D, Joehanes Roby, Assimes Themistocles L, McPherson Ruth, Samani Nilesh J, Erdmann Jeanette, Schunkert Heribert, Courchesne Paul, Munson Peter J, Johnson Andrew D, O'Donnell Christopher J, Zhang Bin, Larson Martin G, Freedman Jane E, Levy Daniel, Yang Xia

Abstract excerpt

OBJECTIVE: The roles of microRNAs (miRNAs) in coronary heart disease (CHD) have not been well characterized. This study sought to systematically characterize the complex genomic architecture of CHD by integrating whole blood miRNA and mRNA expression with genetic variation in 186 CHD cases and 186 controls. APPROACH AND RESULTS: At false discovery rate <0.2, 15 miRNAs were differentially expressed between CHD...

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Identifiers

PMID: 25657313
DOI: 10.1161/ATVBAHA.114.305176
PMCID: PMC4376567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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