Article
Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation.
G3 (Bethesda, Md.) - 3 Feb 2015
Roux Pierre-François, Boitard Simon, Blum Yuna, Parks Brian, Montagner Alexandra, Mouisel Etienne, Djari Anis, Esquerré Diane, Désert Colette, Boutin Morgane, Leroux Sophie, Lecerf Frédéric, Le Bihan-Duval Elisabeth, Klopp Christophe, Servin Bertrand, Pitel Frédérique, Duclos Michel Jean, Guillou Hervé, Lusis Aldons J, Demeure Olivier, Lagarrigue Sandrine
Abstract excerpt
Very few causal genes have been identified by quantitative trait loci (QTL) mapping because of the large size of QTL, and most of them were identified thanks to functional links already known with the targeted phenotype. Here, we propose to combine selection signature detection, coding SNP annotation, and cis-expression QTL analyses to identify potential causal genes underlying QTL identified in divergent line...
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