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Article

miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor.

Journal of molecular cell biology - 1 Feb 2015

Chu Bo, Zhong Liangwen, Dou Shuang, Wang Jun, Li Jianmin, Wang Mingwei, Shi Qinghua, Mei Yide, Wu Mian

Abstract excerpt

Embryo implantation is a crucial step in mammalian reproduction. However, little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation. Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation. Both transient and prolonged transgenic expression of miR-181 led to impaired implantation, which can be rescued by exogenous...

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PMID: 25635127
DOI: 10.1093/jmcb/mjv006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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