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Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients

13 Jan 2015

Abstract excerpt

BACKGROUND: The dysregulation of transforming growth factor-β (TGF-β) signaling plays a crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties. Classified as a member of the ATP-binding cassette (ABC) family, ABCA1 was previously identified by methylated DNA immunoprecipitation microarray (mDIP-Chip) to be methylated in ovarian cancer cell lines, A2780 and CP70. By microarray, it...

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PMID: 25628764
DOI: 10.1186/s13148-014-0036-2

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