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Extracellular Onchocerca-derived small RNAs in host nodules and blood

26 Jan 2015

Abstract excerpt

BACKGROUND: microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of murine and dog hosts infected with the filarial nematodes Litomosoides sigmodontis and Dirofilaria immitis, respectively. Here we identify extracellular, parasite-derived...

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PMID: 25623184
DOI: 10.1186/s13071-015-0656-1

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