Article
The fine-scale and complex architecture of human copy-number variation.
American journal of human genetics - 1 Mar 2008
Perry George H, Ben-Dor Amir, Tsalenko Anya, Sampas Nick, Rodriguez-Revenga Laia, Tran Charles W, Scheffer Alicia, Steinfeld Israel, Tsang Peter, Yamada N Alice, Park Han Soo, Kim Jong-Il, Seo Jeong-Sun, Yakhini Zohar, Laderman Stephen, Bruhn Laurakay, Lee Charles
Abstract excerpt
Despite considerable excitement over the potential functional significance of copy-number variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of CNV regions in the human genome. In this study, we used a high-resolution array-based comparative genomic hybridization (aCGH) platform that targeted known CNV regions of the human genome at approximately 1 kb resolution to...
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