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Article

Modeling the natural history of Pelizaeus-Merzbacher disease.

Neurobiology of disease - 1 Mar 2015

Mayer Joshua A, Griffiths Ian R, Goldman James E, Smith Chelsey M, Cooksey Elizabeth, Radcliff Abigail B, Duncan Ian D

Abstract excerpt

Major gaps in our understanding of the leukodystrophies result from their rarity and the lack of tissue for the interdisciplinary studies required to extend our knowledge of the pathophysiology of the diseases. This study details the natural evolution of changes in the CNS of the shaking pup (shp), a model of the classical form of the X-linked disorder Pelizaeus-Merzbacher disease, in particular in glia, myelin,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25562656
DOI: 10.1016/j.nbd.2014.12.023
PMCID: PMC4492172

Genes

PLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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