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Article

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

Infection and immunity - 1 Mar 2015

Cho Christine, Chande Aroon, Gakhar Lokesh, Bakaletz Lauren O, Jurcisek Joseph A, Ketterer Margaret, Shao Jian, Gotoh Kenji, Foster Eric, Hunt Jason, O'Brien Erin, Apicella Michael A

Abstract excerpt

Nontypeable Haemophilus influenzae (NTHI) forms biofilms in the middle ear during human infection. The biofilm matrix of NTHI contains extracellular DNA. We show that NTHI possesses a potent nuclease, which is a homolog of the thermonuclease of Staphylococcus aureus. Using a biofilm dispersal ass...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25547799
DOI: 10.1128/IAI.02601-14
PMCID: PMC4333478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25547799-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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