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Article

Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus.

Infection and immunity - 1 Mar 2015

Kaiser Julienne C, Omer Sameha, Sheldon Jessica R, Welch Ian, Heinrichs David E

Abstract excerpt

The branched-chain amino acids (BCAAs; Ile, Leu, and Val) not only are important nutrients for the growth of Staphylococcus aureus but also are corepressors for CodY, which regulates virulence gene expression, implicating BCAAs as an important link between the metabolic state of the cell and virulence. BCAAs are either synthesized intracellularly or acquired from the environment. S. aureus encodes three putative...

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PMID: 25547798
DOI: 10.1128/IAI.02542-14
PMCID: PMC4333469

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