Article
Overdominance effect of the bovine ghrelin receptor (GHSR1a)-DelR242 locus on growth in Japanese Shorthorn weaner bulls: heterozygote advantage in bull selection and molecular mechanisms.
G3 (Bethesda, Md.) - 23 Dec 2014
Komatsu Masanori, Sato Yoichi, Negami Tatsuki, Terada Tohru, Sasaki Osamu, Yasuda Jumpei, Arakawa Aisaku, Yoshida Chikara, Takahashi Hideaki, Malau-Aduli Aduli E O, Suzuki Keiichi, Shimizu Kentaro
Abstract excerpt
Ghrelin and the ghrelin receptor (GHSR1a) are involved in growth hormone secretion, food intake, and several other important functions. Ghrelin acts on GHSR1a and induces signal transduction via the Gαq subunit. In our previous study, we identified the DelR242 (3R) allele, a truncated 3-arginine residue (3R) [major type: 4 arginine residues (4R)] of the third intracellular loop of GHSR1a, with a high frequency in...
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