Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.

doi:10.1371/journal.pgen.1004854

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Article

Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.

PLoS genetics - 1 Dec 2014

Tönjes Anke, Scholz Markus, Breitfeld Jana, Marzi Carola, Grallert Harald, Gross Arnd, Ladenvall Claes, Schleinitz Dorit, Krause Kerstin, Kirsten Holger, Laurila Esa, Kriebel Jennifer, Thorand Barbara, Rathmann Wolfgang, Groop Leif, Prokopenko Inga, Isomaa Bo, Beutner Frank, Kratzsch Jürgen, Thiery Joachim, Fasshauer Mathias, Klöting Nora, Gieger Christian, Blüher Matthias, Stumvoll Michael, Kovacs Peter

Abstract excerpt

Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for serum chemerin in three independent cohorts from Europe: Sorbs and KORA from Germany and PPP-Botnia from Finland (total N = 2,791). In addition, we measured mRNA...

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PMID: 25521368
DOI: 10.1371/journal.pgen.1004854
PMCID: PMC4270463

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RARRES2

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