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The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse

15 Dec 2014

Abstract excerpt

The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we used germ-free C57BL/6J mice to demonstrate that gut bacteria are necessary and sufficient for weight gain caused by oral delivery of olanzapine. Second, we surveyed...

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PMID: 25506936
DOI: 10.1371/journal.pone.0115225

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