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Endothelial nitric oxide synthase (eNOS) T-786C, 4a4b, and G894T polymorphisms and male infertility: study for idiopathic asthenozoospermia and meta-analysis.

Biology of reproduction - 1 Feb 2015

Song Pingping, Zou Shasha, Chen Tingting, Chen Jianhua, Wang Yanan, Yang Juanjuan, Song Zhijian, Jiang Huayu, Shi Huijuan, Huang Yiran, Li Zheng, Shi Yongyong, Hu Hongliang

Abstract excerpt

Recent studies on the eNOS gene and male infertility show that expression of eNOS regulates normal spermatogenesis in the testis, and the eNOS gene variants (T-786C, 4a4b, and G894T) are potentially involved in impairment of spermatogenesis and sperm function. Thus, we conducted this association and meta-analysis study to further validate whether variants of those three loci affected the risk of idiopathic...

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PMID: 25505202
DOI: 10.1095/biolreprod.114.123240

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