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CRISPR/Cas9-mediated genome editing of Epstein–Barr virus in human cells

12 Dec 2014

Abstract excerpt

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated 9) system is a highly efficient and powerful tool for RNA-guided editing of the cellular genome. Whether CRISPR/Cas9 can also cleave the genome of DNA viruses such as Epstein-Barr virus (EBV), which undergo episomal replication in human cells, remains to be established. Here, we reported on CRISPR/Cas9-mediated editing...

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PMID: 25502645
DOI: 10.1099/jgv.0.000012

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