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Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity

1 Dec 2014

Abstract excerpt

Poor understanding of the basic biology of Mycobacterium tuberculosis (MTB), the etiological agent of tuberculosis, hampers development of much-needed drugs, vaccines, and diagnostic tests. Better experimental tools are needed to expedite investigations of this pathogen at the systems level. Here, we present a functional MTB proteome microarray covering most of the proteome and an ORFome library. We demonstrate...

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PMID: 25497094
DOI: 10.1016/j.celrep.2014.11.023

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