Article
Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000
Jiao Yuchen, Lumpkins Kimberly, Terhune Julia, Hruban Ralph H, Klein Alison, Kinzler Kenneth W, Papadopoulos Nickolas, Vogelstein Bert, Strauch Eric
Abstract excerpt
A 3 day old infant with persistent severe hypoglycemia was found to have a cystic pancreatic tumor. Cessation of glucose infusion led to severe hypoglycemia. Pancreaticoduodenectomy was performed and revealed an intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia. Sequencing of the IPMN revealed a KRAS gene mutation not present in surrounding normal tissues. Deep sequencing of the patient's...
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