Article
Metabolic variability in bioprocessing: implications of microbial phenotypic heterogeneity.
Trends in biotechnology - 1 Dec 2014
Delvigne Frank, Zune Quentin, Lara Alvaro R, Al-Soud Waleed, Sørensen Søren J
Abstract excerpt
Phenotypic heterogeneity is a major issue in the context of industrial bioprocessing. Stochasticity of gene expression is usually considered to be the main source of heterogeneity among microbial population, but recent evidence demonstrates that metabolic reactions can also be subject to stochasticity without any intervention of gene expression. Although metabolic heterogeneity can be encountered in...
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