Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates.

doi:10.1016/j.ajpath.2014.09.009

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Article

Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates.

The American journal of pathology - 1 Jan 2015

Fiorentino Teresa Vanessa, Owston Michael, Abrahamian Gregory, La Rosa Stefano, Marando Alessandro, Perego Carla, Di Cairano Eliana S, Finzi Giovanna, Capella Carlo, Sessa Fausto, Casiraghi Francesca, Paez Ana, Adivi Ashwin, Davalli Alberto, Fiorina Paolo, Guardado Mendoza Rodolfo, Comuzzie Anthony G, Sharp Mark, DeFronzo Ralph A, Halff Glenn, Dick Edward J, Folli Franco

Abstract excerpt

In this study, we aimed to evaluate the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates. To this end, 52 baboons (Papio hamadryas) underwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks. Histological analysis, immunohistochemistry, Computer Assisted Stereology Toolbox morphometry, and immunofluorescence staining were performed at...

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PMID: 25447052
DOI: 10.1016/j.ajpath.2014.09.009
PMCID: PMC4278248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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