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Article

ACTN3 R577X genotypes associate with Class II and deepbite malocclusions.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics - 1 Nov 2014

Zebrick Brian, Teeramongkolgul Teesit, Nicot Romain, Horton Michael J, Raoul Gwenael, Ferri Joel, Vieira Alexandre R, Sciote James J

Abstract excerpt

INTRODUCTION: α-Actinins are myofibril anchor proteins that influence the contractile properties of skeletal muscles. ACTN2 is expressed in slow type I and fast type II fibers, whereas ACTN3 is expressed only in fast fibers. ACTN3 homozygosity for the 577X stop codon (ie, changing 577RR to 577XX, the R577X polymorphism) results in the absence of α-actinin-3 in about 18% of Europeans, diminishes fast contractile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25439211
DOI: 10.1016/j.ajodo.2014.07.021
PMCID: PMC4254725

Genes

ACTN3
ACTN2

Variants

Provenance

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