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Article

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial.

Journal of the National Cancer Institute - 1 Jan 2015

Manchanda Ranjit, Loggenberg Kelly, Sanderson Saskia, Burnell Matthew, Wardle Jane, Gessler Sue, Side Lucy, Balogun Nyala, Desai Rakshit, Kumar Ajith, Dorkins Huw, Wallis Yvonne, Chapman Cyril, Taylor Rohan, Jacobs Chris, Tomlinson Ian, McGuire Alistair, Beller Uziel, Menon Usha, Jacobs Ian

Abstract excerpt

BACKGROUND: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages. We directly compared the psychological/quality-of-life consequences of such an approach to family history (FH)-based testing. METHODS: In a randomized controlled trial of BRCA1/2 gene-mutation testing in the...

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Identifiers

PMID: 25435541
DOI: 10.1093/jnci/dju379
PMCID: PMC4301703

Genes

BRCA1
BRCA2

Provenance

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