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Article

Affecting Pseudomonas aeruginosa phenotypic plasticity by quorum sensing dysregulation hampers pathogenicity in murine chronic lung infection.

PloS one - 1 Jan 2014

Bondí Roslen, Messina Marco, De Fino Ida, Bragonzi Alessandra, Rampioni Giordano, Leoni Livia

Abstract excerpt

In Pseudomonas aeruginosa quorum sensing (QS) activates the production of virulence factors, playing a critical role in pathogenesis. Multiple negative regulators modulate the timing and the extent of the QS response either in the pre-quorum or post-quorum phases of growth. This regulation likely increases P. aeruginosa phenotypic plasticity and population fitness, facilitating colonization of challenging...

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Identifiers

PMID: 25420086
DOI: 10.1371/journal.pone.0112105
PMCID: PMC4242533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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