Article
Rare variation facilitates inferences of fine-scale population structure in humans.
Molecular biology and evolution - 1 Mar 2015
O'Connor Timothy D, Fu Wenqing, Mychaleckyj Josyf C, Logsdon Benjamin, Auer Paul, Carlson Christopher S, Leal Suzanne M, Smith Joshua D, Rieder Mark J, Bamshad Michael J, Nickerson Deborah A, Akey Joshua M
Abstract excerpt
Understanding the genetic structure of human populations has important implications for the design and interpretation of disease mapping studies and reconstructing human evolutionary history. To date, inferences of human population structure have primarily been made with common variants. However, recent large-scale resequencing studies have shown an abundance of rare variation in humans, which may be particularly...
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