Article
The single nucleotide polymorphism +936 C/T VEGF is associated with human epidermal growth factor receptor 2 expression in Moroccan breast cancer women.
Medical oncology (Northwood, London, England) - 1 Dec 2014
Rahoui Jalila, Sbitti Yassir, Touil Nadia, Laraqui Abdelilah, Ibrahimi Azeddine, Rhrab Brahim, Al Bouzidi Abderrahman, Moussaoui Rahali Driss, Dehayni Mohamed, Ichou Mohamed, Zaoui Fatima, Mrani Saad
Abstract excerpt
The vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is involved in the development and progression of breast cancer (BC). The functional +936 C/T polymorphism of the VEGF-A gene has been implicated in BC susceptibility; however, published data are conflicting. In the current case-control study, we analyzed the association of the +936 C/T polymorphism with BC risk and tumor markers...
Topics
- 3' Untranslated Regions
- Adult
- Aged
- Biomarkers, Tumor
- Breast Neoplasms
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease