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How to use: the direct antiglobulin test in newborns

13 Nov 2014

Abstract excerpt

The direct antiglobulin test (DAT) detects the presence of immunoglobulin, complement or both bound to the red blood cell membrane. The test, historically called the 'Coombs test', was first described in 1945 by Cambridge immunologist Robin Coombs. Suspected haemolytic disease of the newborn, due to either Rhesus disease or ABO incompatibility, is one of most common reasons for requesting a DAT in newborns. In...

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PMID: 25395493
DOI: 10.1136/archdischild-2013-305553

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