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Alterations in Gene Expression and DNA Methylation during Murine and Human Lung Alveolar Septation

11 Nov 2014

Abstract excerpt

DNA methylation, a major epigenetic mechanism, may regulate coordinated expression of multiple genes at specific time points during alveolar septation in lung development. The objective of this study was to identify genes regulated by methylation during normal septation in mice and during disordered septation in bronchopulmonary dysplasia. In mice, newborn lungs (preseptation) and adult lungs (postseptation) were...

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PMID: 25387348
DOI: 10.1165/rcmb.2014-0160oc

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