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Article

Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway

7 Nov 2014

Abstract excerpt

A major hurdle in vaccine development is the difficulty in identifying relevant target epitopes and then presenting them to the immune system in a context that mimics their native conformation. We have engineered novel virus-like-particle (VLP) technology that is able to display complex libraries of random peptide sequences on a surface-exposed loop in the coat protein without disruption of protein folding or VLP...

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PMID: 25379726
DOI: 10.1371/journal.pone.0111198

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