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Article

STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.

Oncotarget - 30 Nov 2014

Jo Dong Hyun, Kim Jin Hyoung, Cho Chang Sik, Cho Young-Lai, Jun Hyoung Oh, Yu Young Suk, Min Jeong-Ki, Kim Jeong Hun

Abstract excerpt

Retinoblastoma, the most common intraocular malignant tumor in children, is characterized by the loss of both functional alleles of RB1 gene, which however alone cannot maintain malignant characteristics of retinoblastoma cells. Nevertheless, the investigation of other molecular aberrations such as matrix metalloproteinases (MMPs) and miRNAs is still lacking. In this study, we demonstrate that STAT3 is activated...

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Source

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Identifiers

PMID: 25359779
DOI: 10.18632/oncotarget.2546
PMCID: PMC4294389

Genes

STAT3
BCL2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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