Article
Streptomycin decreases the functional shift to a slow phenotype induced by electrical stimulation in engineered muscle.
Tissue engineering. Part A - 1 Mar 2015
Khodabukus Alastair, Baar Keith
Abstract excerpt
Chronic low-frequency stimulation (CLFS) has long been used to induce a fast-to-slow phenotype shift in skeletal muscle. In this study, we explore the role of frequency (10 and 20 Hz), active time (15-60%), and streptomycin in inducing a fast-to-slow shift in engineered muscle. We found that C2C12 engineered muscle could respond to CLFS with an adult-like active time of 60% and found that a constant 10 Hz train...
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