Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic.

doi:10.1158/1078-0432.CCR-14-1293

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Article

Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014

Jardim Denis L F, Tang Chad, Gagliato Debora De Melo, Falchook Gerald S, Hess Kenneth, Janku Filip, Fu Siqing, Wheler Jennifer J, Zinner Ralph G, Naing Aung, Tsimberidou Apostolia M, Holla Vijaykumar, Li Marylin M, Roy-Chowdhuri Sinchita, Luthra Raja, Salgia Ravi, Kurzrock Razelle, Meric-Bernstam Funda, Hong David S

Abstract excerpt

PURPOSE: This study aimed to assess MET amplification among different cancers, association with clinical factors and genetic aberrations and targeted therapy response modifications. EXPERIMENTAL DESIGN: From May 2010 to November 2012, samples from patients with advanced tumors referred to the MD Anderson Phase I Clinic were analyzed for MET gene amplification by FISH. Patient demographic, histologic...

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PMID: 25326232
DOI: 10.1158/1078-0432.CCR-14-1293

Genes

MET
BRAF
PTEN

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