Article
Measuring epigenetics as the mediator of gene/environment interactions in DOHaD.
Journal of developmental origins of health and disease - 1 Feb 2015
Ong M-L, Lin X, Holbrook J D
Abstract excerpt
Analysis of DNA methylation data in epigenome-wide association studies provides many bioinformatics and statistical challenges. Not least of these, are the non-independence of individual DNA methylation marks from each other, from genotype and from technical sources of variation. In this review we discuss DNA methylation data from the Infinium450K array and processing methodologies to reduce technical variation....
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