Article
Inborn errors of cytoplasmic triglyceride metabolism.
Journal of inherited metabolic disease - 1 Jan 2015
Wu Jiang Wei, Yang Hao, Wang Shu Pei, Soni Krishnakant G, Brunel-Guitton Catherine, Mitchell Grant A
Abstract excerpt
Triglyceride (TG) synthesis, storage, and degradation together constitute cytoplasmic TG metabolism (CTGM). CTGM is mostly studied in adipocytes, where starting from glycerol-3-phosphate and fatty acyl (FA)-coenzyme A (CoA), TGs are synthesized then stored in cytoplasmic lipid droplets. TG hydrolysis proceeds sequentially, producing FAs and glycerol. Several reactions of CTGM can be catalyzed by more than one...
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