Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.

Journal of experimental & clinical cancer research : CR - 11 Oct 2014

Rotella Virginia, Fornaro Lorenzo, Vasile Enrico, Tibaldi Carmelo, Boldrini Laura, Chella Antonio, D'Incecco Armida, Cirigliano Giovanna, Chioni Aldo, Lupi Cristiana, Sensi Elisa, Ginocchi Laura, Giovannelli Simona, Pennucci Maria Cristina, Fontanini Gabriella, Baldini Editta

Abstract excerpt

BACKGROUND: We aimed at investigating the outcomes of female patients with stage IIIB-IV adenocarcinoma of the lung according to EGFR and K-Ras mutational status. METHODS: One hundred and three consecutive female patients genotyped at a single Italian Institution were analyzed. Patients were planned to receive first-line platinum-based chemotherapy (CT) and a salvage treatment with anti-EGFR tyrosine-kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Combined Chemotherapy Protocols

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to Salvage Therapy

Source

Open in PubMed Open full text

Identifiers

PMID: 25300933
DOI: 10.1186/s13046-014-0077-6
PMCID: PMC4198726

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.PMID 25300933Read ↗

Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: a population-based prospective study.Semantic proximity Read ↗

NSCLC Patients Harbouring Rare or Complex EGFR Mutations Are More Often Smokers and Might Not Benefit from First-Line Tyrosine Kinase Inhibitor Therapy.Semantic proximity Read ↗

Specificities of lung adenocarcinoma in women who have never smoked.Semantic proximity Read ↗

Characteristics of lung cancer in women: importance of hormonal and growth factors.Semantic proximity Read ↗

Response to first-line chemotherapy in patients with non-small-cell lung cancer according to epidermal growth factor receptor and K-RAS mutation status.Semantic proximity Read ↗

Women and lung cancer: clinical and molecular profiling as a determinate for treatment decisions: a literature review.Semantic proximity Read ↗

Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.Semantic proximity Read ↗

Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating Epidermal Growth Factor Receptor mutation: implications for clinical practice and open issues.Semantic proximity Read ↗

Subtype-specific KRAS mutations in advanced lung adenocarcinoma: a retrospective study of patients treated with platinum-based chemotherapy.Semantic proximity Read ↗

EGFR activating mutations and their association with response to platinum-doublet chemotherapy in Brazilian non-small cell lung cancer patients.Semantic proximity Read ↗

Rationale for treatment and study design of tailor: a randomized phase III trial of second-line erlotinib versus docetaxel in the treatment of patients affected by advanced non-small-cell lung cancer with the absence of epidermal growth factor receptor mutations.Semantic proximity Read ↗

Race, gender and mutations in the prediction of anti-EGFR activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.