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Article

REG4 independently predicts better prognosis in non-mucinous colorectal cancer.

PloS one - 1 Jan 2014

Kaprio Tuomas, Hagström Jaana, Mustonen Harri, Koskensalo Selja, Andersson Leif C, Haglund Caj

Abstract excerpt

INTRODUCTION: Colorectal cancer (CRC) is one of the world's three most common cancers and its incidence is rising. To identify patients who benefit from adjuvant therapy requires novel biomarkers. The regenerating islet-derived gene (REG) 4 belongs to a group of small secretory proteins involved in cell proliferation and regeneration. Its up-regulated expression occurs in inflammatory bowel diseases also in...

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Source

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Identifiers

PMID: 25295732
DOI: 10.1371/journal.pone.0109600
PMCID: PMC4190354

Genes

REG4
MUC2
MUC1
MUC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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REG4 independently predicts better prognosis in non-mucinous colorectal cancer.PMID 25295732Read ↗

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Evaluation of Galanin Expression in Colorectal Cancer: An Immunohistochemical and Transcriptomic StudySemantic proximity Read ↗

REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisationSemantic proximity Read ↗

Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancerSemantic proximity Read ↗

Regenerating gene (REG) product and its potential clinical usageSemantic proximity Read ↗

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Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers.Semantic proximity Read ↗

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