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Article

Whole-exome sequencing to decipher the genetic heterogeneity of hearing loss in a Chinese family with deaf by deaf mating.

PloS one - 1 Jan 2014

Qing Jie, Yan Denise, Zhou Yuan, Liu Qiong, Wu Weijing, Xiao Zian, Liu Yuyuan, Liu Jia, Du Lilin, Xie Dinghua, Liu Xue Zhong

Abstract excerpt

Inherited deafness has been shown to have high genetic heterogeneity. For many decades, linkage analysis and candidate gene approaches have been the main tools to elucidate the genetics of hearing loss. However, this associated study design is costly, time-consuming, and unsuitable for small families. This is mainly due to the inadequate numbers of available affected individuals, locus heterogeneity, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25289672
DOI: 10.1371/journal.pone.0109178
PMCID: PMC4188603

Genes

MYH14
WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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