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Article

Increased genomic instability may contribute to the development of kinase domain mutations in chronic myeloid leukemia.

International journal of hematology - 1 Dec 2014

Sweet Kendra, Al Ali Najla H, Dalia Samir M, Komrokji Rami S, Crescentini Robert M, Tinsley Sara, Lancet Jeffrey E, Papenhausen Peter R, Zhang Ling, Pinilla-Ibarz Javier

Abstract excerpt

Imatinib resistance in chronic myeloid leukemia (CML) is commonly due to BCR-ABL kinase domain mutations (KDMs). In this single-institution retrospective analysis, patients with KDMs were identified from a cohort of patients treated for CML at our institution. Clinical outcomes were assessed based on the characteristics of the KDMs and results of cytogenetic analysis. In total, we compared 26 patients with KDM to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fusion Proteins, bcr-abl

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Source

Identifiers

PMID: 25281405
DOI: 10.1007/s12185-014-1685-9

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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