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Article

MEK inhibitor for gastric cancer with MEK1 gene mutations.

Molecular cancer therapeutics - 1 Dec 2014

Sogabe Shunsuke, Togashi Yosuke, Kato Hiroaki, Kogita Akihiro, Mizukami Takuro, Sakamoto Yoichi, Banno Eri, Terashima Masato, Hayashi Hidetoshi, de Velasco Marco A, Sakai Kazuko, Fujita Yoshihiko, Tomida Shuta, Yasuda Takushi, Takeyama Yoshifumi, Okuno Kiyotaka, Nishio Kazuto

Abstract excerpt

The prognosis for patients with unresectable advanced or recurrent gastric cancer remains poor. The identification of additional oncogenes with influences similar to those of epidermal growth factor receptor gene mutations, upon which the growth of cancer cells is dependent, is needed. In this study, we evaluated sensitivity to MEK inhibitors (GSK1120212 and PD0325901) in several gastric cancer cell lines in...

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Identifiers

PMID: 25253779
DOI: 10.1158/1535-7163.MCT-14-0429

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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