Article
Genetic variation within the Mx gene of commercially selected chicken lines reveals multiple haplotypes, recombination and a protein under selection pressure.
PloS one - 1 Jan 2014
Fulton Janet E, Arango Jesus, Ali Rizwana A, Bohorquez Elaine B, Lund Ashlee R, Ashwell Chris M, Settar Petek, O'Sullivan Neil P, Koci Matthew D
Abstract excerpt
The Mx protein is one of the best-characterized interferon-stimulated antiviral mediators. Mx homologs have been identified in most vertebrates examined; however, their location within the cell, their level of activity, and the viruses they inhibit vary widely. Recent studies have demonstrated multiple Mx alleles in chickens and some reports have suggested a specific variant (S631N) within exon 14 confers...
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