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Article

Experience with afatinib in patients with non-small cell lung cancer progressing after clinical benefit from gefitinib and erlotinib.

The oncologist - 1 Oct 2014

Schuler Martin, Fischer Jürgen R, Grohé Christian, Gütz Sylvia, Thomas Michael, Kimmich Martin, Schneider Claus-Peter, Laack Eckart, Märten Angela

Abstract excerpt

BACKGROUND: Afatinib, an irreversible ErbB family blocker, demonstrated superiority to chemotherapy as first-line treatment in patients with EGFR-mutated non-small cell lung cancer (NSCLC). Afatinib is also active in patients progressing on EGFR tyrosine kinase inhibitors (EGFR-TKIs). We report the results of a large cohort of NSCLC patients receiving afatinib within a compassionate-use program (CUP). PATIENTS...

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Share to Afatinib
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

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Source

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Identifiers

PMID: 25232040
DOI: 10.1634/theoncologist.2014-0103
PMCID: PMC4200993

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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