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Article

Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes.

Diabetes care - 1 Dec 2014

Myngheer Nele, Allegaert Karel, Hattersley Andrew, McDonald Tim, Kramer Holger, Ashcroft Frances M, Verhaeghe Johan, Mathieu Chantal, Casteels Kristina

Abstract excerpt

OBJECTIVE: Sulfonylureas (SUs) are effective at controlling glycemia in permanent neonatal diabetes mellitus (PNDM) caused by KCNJ11 (Kir6.2) mutations. RESEARCH DESIGN AND METHODS: We report the case of a woman with PNDM who continued high doses of glibenclamide (85 mg/day) during her pregnancy. The baby was born preterm, and presented with macrosomia and severe hyperinsulinemic hypoglycemia requiring high-rate...

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Source

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Identifiers

PMID: 25231897
DOI: 10.2337/dc14-1247
PMCID: PMC5894804

Genes

KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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