Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of heterosynaptic LTD in the human nociceptive system: superficial skin neuromodulation using a matrix electrode reduces deep pain sensitivity.

PloS one - 1 Jan 2014

Mücke Martin, Cuhls Henning, Radbruch Lukas, Weigl Tobias, Rolke Roman

Abstract excerpt

Long term depression (LTD) is a neuronal learning mechanism after low frequency stimulation (LFS). This study compares two types of electrodes (concentric vs. matrix) and stimulation frequencies (4 and 30 Hz) to examine homo- and heterosynaptic effects indirectly depicted from the somatosensory profile of healthy subjects. Both electrodes were compared in a prospective, randomized, controlled cross-over study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electric Stimulation
Share to Electrodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanical Phenomena

Share to Pain Threshold

Share to Somatosensory Cortex

Share to Synapses

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 25229556
DOI: 10.1371/journal.pone.0107718
PMCID: PMC4168234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of heterosynaptic LTD in the human nociceptive system: superficial skin neuromodulation using a matrix electrode reduces deep pain sensitivity.PMID 25229556Read ↗

Mechanistically Informed Non-invasive Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: a Randomised Double-blind Sham-controlled Trial.Semantic proximity Read ↗

Neural stimulation and recording performance in human somatosensory cortex over 1500 daysSemantic proximity Read ↗

Neural network-based alterations during repeated heat pain stimulation in major depressionSemantic proximity Read ↗

Assessing the predictive value of peak alpha frequency for the sensitivity to painSemantic proximity Read ↗

Neural Mechanisms of tDCS: Insights from an In-Vivo Rodent Model with Realistic Electric Field StrengthsSemantic proximity Read ↗

“Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings”Semantic proximity Read ↗

Fibromyalgia: a primer for the anesthesia community.Semantic proximity Read ↗

Effects of transcranial direct current stimulation, associated with manual vagus nerve therapy, on pain in women with fibromyalgia: Study protocol for a double-blind, randomized, controlled clinical trial.Semantic proximity Read ↗

Tactile Perception and Tolerability Thresholds of TMS Characterized by Intensity across Locations and FrequenciesSemantic proximity Read ↗

Phasic Neural Stimulation via Frequency-Modulated Kilohertz Signals: An Alternative to Amplitude ModulationSemantic proximity Read ↗

EEG-Based Pain Detection Using Kernel Spectral Connectivity Network with Preserved Spatio-Frequency InterpretabilitySemantic proximity Read ↗

Dynamic Pain Phenotypes are Associated with Spinal Cord Stimulation-Induced Reduction in Pain: A Repeated Measures Observational Pilot Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.