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Article

Ligand-induced protein responses and mechanical signal propagation described by linear response theories.

Biophysical journal - 16 Sept 2014

Yang Lee-Wei, Kitao Akio, Huang Bang-Chieh, Gō Nobuhiro

Abstract excerpt

In this study, a general linear response theory (LRT) is formulated to describe time-dependent and -independent protein conformational changes upon CO binding with myoglobin. Using the theory, we are able to monitor protein relaxation in two stages. The slower relaxation is found to occur from 4.4 to 81.2 picoseconds and the time constants characterized for a couple of aromatic residues agree with those observed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25229149
DOI: 10.1016/j.bpj.2014.07.049
PMCID: PMC4167303

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