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Article

Paternal influence of sperm DNA integrity on early embryonic development

8 Sept 2014

Abstract excerpt

STUDY QUESTION: Does sperm DNA damage affect early embryonic development? SUMMARY ANSWER: Increased sperm DNA damage adversely affects embryo quality starting at Day 2 of early embryonic development and continuing after embryo transfer, resulting in reduced implantation rates and pregnancy outcomes. WHAT IS KNOWN ALREADY: Abnormalities in the sperm DNA in the form of single and double strand breaks can be...

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PMID: 25205757
DOI: 10.1093/humrep/deu228

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