Human papillomavirus infection in <scp>B</scp>owen disease: Negative p53 expression, not p16<scp>^INK</scp>^4a overexpression, is correlated with human papillomavirus‐associated <scp>B</scp>owen disease

Abstract excerpt

Genital Bowen disease (BD) has been linked to the high-risk types of human papillomavirus (HPV) infection. Recently, it has been recognized that HPV also can be associated with extragenital BD. HPV oncoproteins E6 and E7 interfere with the function of p53 and pRb, respectively, leading carcinogenesis. p16(INK4a) overexpression induced by inactivation of pRb is recognized as a surrogate marker for HPV-associated...

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