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Article

To reflex or not: additional BRCA1/2 testing in Ashkenazi Jewish individuals without founder mutations.

Journal of genetic counseling - 1 Apr 2015

Petrucelli Nancie, Mange Sarah, Fulbright Jennifer L, Dohany Lindsay, Zakalik Dana, Duquette Debra

Abstract excerpt

This study determined the prevalence of non-Ashkenazi Jewish BRCA1/2 mutations in the Ashkenazi Jewish population in the state of Michigan, current provider testing practices, and the use of mutation probability models in determining which Ashkenazi Jewish individuals should be offered further analysis following negative BRCA1/2 founder testing. Testing patterns, mutation probabilities, and testing results were...

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Identifiers

PMID: 25199548
DOI: 10.1007/s10897-014-9762-z

Genes

BRCA1

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