Genetic manipulation of autophagy in the Drosophila ovary.

Abstract excerpt

Flies with mutations in Atg7 or Atg8a are homozygous viable and develop to adulthood, whereas mutations in other autophagy genes, including Atg1, are homozygous lethal. Clonal analysis has been instrumental in examining the role and regulation of lethal Atg genes in many aspects of Drosophila development and survival. The generation of homozygous mutant clones in an otherwise heterozygous mutant background is...

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