Article
Desmin mutations impact the autophagy flux in C2C12 cell in mutation-specific manner.
Cell and tissue research - 1 Aug 2023
Sukhareva K S, Smolina N A, Churkina A I, Kalugina K K, Zhuk S V, Khudiakov A A, Khodot A A, Faggian G, Luciani G B, Sejersen T, Kostareva A A
Abstract excerpt
Desmin is the main intermediate filament of striated and smooth muscle cells and plays a crucial role in maintaining the stability of muscle fiber during contraction and relaxation cycles. Being a component of Z-disk area, desmin integrates autophagic pathways, and the disturbance of Z-disk proteins' structure negatively affects chaperone-assisted selective autophagy (CASA). In the present study, we focused on...
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