Article
H1N1 triggered recurrent acute necrotizing encephalopathy in a family with a T653I mutation in the RANBP2 gene.
The Pediatric infectious disease journal - 1 Mar 2015
Anand Geetha, Visagan Ravindran, Chandratre Saleel, Segal Shelley, Nemeth Andrea H, Squier Waney, Sheerin Fintan, Neilson Derek, Jayawant Sandeep
Abstract excerpt
A 28-month-old infant presented with fever, vomiting and encephalopathy. Magnetic resonance imaging findings and family history confirmed a diagnosis of recurrent familial acute necrotizing encephalopathy (ANE1). We believe that this is the first description implicating the H1N1 viral strain as a trigger and the second report of a T653I mutation in the RANBP2 gene described in relation to ANE1.
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